The species Cannabis spp. produces a
distinctive group of molecules called phytocannabinoids, among which a total of
568 have been counted. Among these, tetrahydrocannabinol (THC), cannabinol
(CBN) and cannabinodiol (CBND) have been found to have psychoactive properties.
Other cannabinoids, such as cannabidiol (CBD) do not have psychoactive
properties. All these compounds are present in the plant, however, to extract
them for medicinal purposes is necessary to perform a process, called
decarboxylation.
The raw material for the production of the
medicinal extracts of the Cannabis spp. are the inflorescences found in the
pistiled individuals (females), which are rich in neutral forms like the
cannabinoid acids, such as the tetrahydrocannabinolic acid (THCA) or the
cannabidiolic acid (CBDA). When these acids are subjected to heat, the process
of decarboxylation occurs and from these neutral forms the active principles
that are THC and CBD are extracted. Also, depending on the temperature and time
of decarboxylation, a degradation product of THC can be obtained which is CBN.
These five cannabinoids are the markers used in the quality control process of
medicinal products.
In conclusion, the Cannabis spp. plant has
a diversity of compounds with medicinal potential, however, the studies to
improve the extraction of these molecules, as well as the clinical trials to
know if the effects on human health are or not significant are still in
process.
References Carvalho,
Virgínia M., Aguiar, Andrey F. L., Baratto, Leopoldo C., Souza, Fábio L. C.,
& Rocha, Ernesto D.. (2020). QUANTIFICAÇÃO DE CANABINOIDES EM EXTRATOS
MEDICINAIS DE Cannabis POR CROMATOGRAFIA LÍQUIDA DE ALTA EFICIÊNCIA. Química
Nova, 43(1), 90-97. Epub March 16, 2020.https://doi.org/10.21577/0100-4042.20170457
Lewis MM, Yang
Y, Wasilewski E, Clarke HA, Kotra LP. CHEMICAL PROFILING OF MEDICAL CANNABIS
EXTRACTS. ACS Omega. 2017 Sep 30;2(9):6091-6103. doi: 10.1021/acsomega.7b00996.
Epub 2017 Sep 22. PMID: 30023762; PMCID: PMC6044620.
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